Gene name:
MT-ND5 (MTND5;NADH5;ND5) ;
Protein name:
NADH-ubiquinone oxidoreductase chain 5 ;
Alternative:
NADH dehydrogenase subunit 5 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Location:
Mitochondrion inner membrane
Multi-pass membrane protein
Protein Attributes:
50:
MTMHTTMTTL | TLTSLIPPIL | TTLVNPNKKN | SYPHYVKSIV | ASTFIISLFP |
100:
TTMFMCLDQE | VIISNWHWAT | TQTTQLSLSF | KLDYFSMMFI | PVALFVTWSI |
150:
MEFSLWYMNS | DPNINQFFKY | LLIFLITMLI | LVTANNLFQL | FIGWEGVGIM |
200:
SFLLISWWYA | RADANTAAIQ | AILYNRIGDI | GFILALAWFI | LHSNSWDPQQ |
250:
MALLNANPSL | TPLLGLLLAA | AGKSAQLGLH | PWLPSAMEGP | TPVSALLHSS |
300:
TMVVAGIFLL | IRFHPLAENS | PLIQTLTLCL | GAITTLFAAV | CALTQNDIKK |
350:
IVAFSTSSQL | GLMMVTIGIN | QPHLAFLHIC | THAFFKAMLF | MCSGSIIHNL |
400:
NNEQDIRKMG | GLLKTMPLTS | TSLTIGSLAL | AGMPFLTGFY | SKDHIIETAN |
450:
MSYTNAWALS | ITLIATSLTS | AYSTRMILLT | LTGQPRFPTL | TNINENNPTL |
500:
LNPIKRLAAG | SLFAGFLITN | NISPASPFQT | TIPLYLKLTA | LAVTFLGLLT |
550:
ALDLNYLTNK | LKMKSPLCTF | YFSNMLGFYP | SITHRTIPYL | GLLTSQNLPL |
600:
LLLDLTWLEK | LLPKTISQHQ | ISTSIITSTQ | KGMIKLYFLS | FFFPLILTLL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Bovine
Dog
Chicken
Rabbit
ELISA Kit for Human NADH-ubiquinone oxidoreductase chain 5
ELISA Kit for Human NADH-ubiquinone oxidoreductase chain 5
ELISA Kit for Human NADH-ubiquinone oxidoreductase chain 5
ELISA Kit for Human NADH-ubiquinone oxidoreductase chain 5
ELISA Kit for Human NADH-ubiquinone oxidoreductase chain 5
ELISA Kit for Human NADH-ubiquinone oxidoreductase chain 5
CLIA Kit for Human NADH-ubiquinone oxidoreductase chain 5
CLIA Kit for Human NADH-ubiquinone oxidoreductase chain 5
CLIA Kit for Human NADH-ubiquinone oxidoreductase chain 5
CLIA Kit for Human NADH-ubiquinone oxidoreductase chain 5
CLIA Kit for Human NADH-ubiquinone oxidoreductase chain 5
CLIA Kit for Human NADH-ubiquinone oxidoreductase chain 5
Polyclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Polyclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Polyclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Polyclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Polyclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Polyclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Monoclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Monoclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Monoclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Monoclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Monoclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Monoclonal Antibody for Human NADH-ubiquinone oxidoreductase chain 5
Protein for Human NADH-ubiquinone oxidoreductase chain 5
Protein for Human NADH-ubiquinone oxidoreductase chain 5
Protein for Human NADH-ubiquinone oxidoreductase chain 5
Protein for Human NADH-ubiquinone oxidoreductase chain 5
Protein for Human NADH-ubiquinone oxidoreductase chain 5
Protein for Human NADH-ubiquinone oxidoreductase chain 5
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Sequence and organization of the human mitochondrial genome."
Anderson S.
,
Bankier A.T.
,
Barrell B.G.
,
de Bruijn M.H.L.
,
Coulson A.R.
,
Drouin J.
,
Eperon I.C.
,
Nierlich D.P.
,
Roe B.A.
,
Sanger F.
,
Schreier P.H.
,
Smith A.J.H.
,
Staden R.
,
Young I.G.
Nature290:457-465(1981)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO 456
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-211; VAL-257 AND VAL-314
tissue :
Placenta .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-257
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION OF PROTEIN
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SER-17; SER-95; PRO-99; ASP-146; VAL-160; SER-165; SER-304; ALA-331 AND GLY-503
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LHON THR-458
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LHON THR-458
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LHON GLU-465
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT MELAS ASN-393
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT THR-475
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LS LEU-124
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS MELAS GLY-145 AND LEU-237
20.
"A missense mutation in the mitochondrial ND5 gene associated with a Leigh-MELAS overlap syndrome."
Crimi M.
,
Galbiati S.
,
Moroni I.
,
Bordoni A.
,
Perini M.P.
,
Lamantea E.
,
Sciacco M.
,
Zeviani M.
,
Biunno I.
,
Moggio M.
,
Scarlato G.
,
Comi G.P.
Neurology60:1857-1861(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LS CYS-250
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LHON VAL-171
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT MELAS THR-236
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LS THR-236;VARIANT MELAS ASN-393
24.
"High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency."
Calvo S.E.
,
Tucker E.J.
,
Compton A.G.
,
Kirby D.M.
,
Crawford G.
,
Burtt N.P.
,
Rivas M.
,
Guiducci C.
,
Bruno D.L.
,
Goldberger O.A.
,
Redman M.C.
,
Wiltshire E.
,
Wilson C.J.
,
Altshuler D.
,
Gabriel S.B.
,
Daly M.J.
,
Thorburn D.R.
,
Mootha V.K.
Nat. Genet.42:851-858(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS MT-C1D LEU-124; ALA-253 AND ASN-393;VARIANT SER-447